Center for Advanced Practice
Publication Title
J Am Heart Assoc
Document Type
Article
PubMed ID
34569246
Abstract
Background Protein-losing enteropathy (PLE) is a significant cause of morbidity and mortality in congenital heart disease patients with single ventricle physiology. Intrahepatic dynamic contrast-enhanced magnetic resonance lymphangiography (IH-DCMRL) is a novel diagnostic technique that may be useful in characterizing pathologic abdominal lymphatic flow in the congenital heart disease population and in diagnosing PLE. The objective of this study was to characterize differences in IH-DCMRL findings in patients with single ventricle congenital heart disease with and without PLE. Methods and Results This was a single-center retrospective study of IH-DCMRL findings and clinical data in 41 consecutive patients, 20 with PLE and 21 without PLE, with single ventricle physiology referred for lymphatic evaluation. There were 3 distinct duodenal imaging patterns by IH-DCMRL: (1) enhancement of the duodenal wall with leakage into the lumen, (2) enhancement of the duodenal wall without leakage into the lumen, and (3) no duodenal involvement. Patients with PLE were more likely to have duodenal involvement on IH-DCMRL than patients without PLE (
Keywords
Fontan Procedure, Heart Defects, Congenital, Humans, Lymphography, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Protein-Losing Enteropathies, Retrospective Studies
DOI
10.1161/JAHA.121.021542
Publication Date
10-5-2021
Citation
Lemley, B., Biko, D., DeWitt, A., Glatz, A., Goldberg, D., Saravanan, M., O'Byrne, M., Pinto, E., Ravishankar, C., Rome, J., Smith, C., & Dori, Y. (2021). Intrahepatic Dynamic Contrast-Enhanced Magnetic Resonance Lymphangiography: Potential Imaging Signature for Protein-Losing Enteropathy in Congenital Heart Disease.. J Am Heart Assoc, 10 (19), 021542-021542. https://doi.org/10.1161/JAHA.121.021542
