Center for Advanced Practice

The coronavirus disease 2019 pandemic is associated with a substantial rise in frequency and severity of presentation of youth-onset type 2 diabetes.

Sheela N Magge
Risa M Wolf
Laura Pyle
Elizabeth A Brown
Valeria C Benavides
Monica E Bianco
Lily C Chao
Anna Cymbaluk
Pinar Gumus Balikcioglu
Kelsee Halpin
Daniel S Hsia
Lina Huerta-Saenz
Jane J Kim
Seema Kumar
Lorraine E Levitt Katz, Children's Hospital of Philadelphia, Philadelphia, PA
Brynn E Marks
Anna Neyman
Katie L O'Sullivan
Sabitha Sasidharan Pillai
Amy S Shah
Ashley H Shoemaker
Juwairriyyah A W Siddiqui
Shylaja Srinivasan
Inas H Thomas
Jeanie B Tryggestad
Maha F Yousif
Megan M Kelsey

Abstract

OBJECTIVES: To evaluate the frequency and severity of new cases of youth-onset type 2 diabetes in the US during the first year of the pandemic compared with the mean of the previous 2 years.

STUDY DESIGN: Multicenter (n = 24 centers), hospital-based, retrospective chart review. Youth aged ≤21 years with newly diagnosed type 2 diabetes between March 2018 and February 2021, body mass index ≥85th percentile, and negative pancreatic autoantibodies were included. Demographic and clinical data, including case numbers and frequency of metabolic decompensation, were compared between groups.

RESULTS: A total of 3113 youth (mean [SD] 14.4 [2.4] years, 50.5% female, 40.4% Hispanic, 32.7% Black, 14.5% non-Hispanic White) were assessed. New cases of type 2 diabetes increased by 77.2% in the year during the pandemic (n = 1463) compared with the mean of the previous 2 years, 2019 (n = 886) and 2018 (n = 765). The likelihood of presenting with metabolic decompensation and severe diabetic ketoacidosis also increased significantly during the pandemic.

CONCLUSIONS: The burden of newly diagnosed youth-onset type 2 diabetes increased significantly during the coronavirus disease 2019 pandemic, resulting in enormous strain on pediatric diabetes health care providers, patients, and families. Whether the increase was caused by coronavirus disease 2019 infection, or just associated with environmental changes and stressors during the pandemic is unclear. Further studies are needed to determine whether this rise is limited to the US and whether it will persist over time.