Case Report: Two Distinct Focal Congenital Hyperinsulinism Lesions Resulting From Separate Genetic Events.
Focal hyperinsulinism (HI) comprises nearly 50% of all surgically treated HI cases and is cured if the focal lesion can be completely resected. Pre-operative localization of the lesion is thus critical. Few cases of hyperinsulinism with multiple focal lesions have been reported, and assessment of the molecular mechanisms driving this rare occurrence has been limited. We present two cases of multifocal HI, each resulting from two independent, pancreatic focal lesions.
beta cells, case report, hypoglycemia, islets, KATP channel, pancreas
Rosenfeld, E., Mitteer, L., Boodhansingh, K., Becker, S., McKnight, H., Boyajian, L., Ackermann, A., Kalish, J., Bhatti, T., States, L., Adzick, N., Lord, K., & De León, D. (2021). Case Report: Two Distinct Focal Congenital Hyperinsulinism Lesions Resulting From Separate Genetic Events.. Front Pediatr, 9, 699129-699129. https://doi.org/10.3389/fped.2021.699129