Center for Advanced Practice
Title
Rate and Risk Factors Associated with Autism Spectrum Disorder in Congenital Diaphragmatic Hernia.
Publication Title
Journal of autism and developmental disorders
Document Type
Article
PubMed ID
29383650
Abstract
To determine the rate and predictors of autism spectrum disorder (ASD) in congenital diaphragmatic hernia (CDH). Between 06/2004 and 09/2015 a total of 110 CDH survivors underwent neurodevelopmental (ND) testing and screening for ASD, followed by a full autism diagnostic evaluation if indicated at our institution. We found a 9 time higher rate of ASD in CDH children compared to the general population (P = 0.0002). Multiple patient-related and clinical variables risk factors of ASD were identified by univariate analysis. However, only short-term and long-term neurodevelopmental delays were strongly associated with ASD in CDH by multivariate comparisons. There is a striking prevalence of ASD in CDH survivors and our findings suggest that all CDH children should be regularly screened for ASD.
Keywords
Autism Spectrum Disorder, Child, Cohort Studies, Female, Follow-Up Studies, Hernias, Diaphragmatic, Congenital, Humans, Infant, Newborn, Male, Neuropsychological Tests, Prospective Studies, Retrospective Studies, Risk Factors
DOI
10.1007/s10803-018-3472-6
Publication Date
6-1-2018
Citation
Danzer, E., Hoffman, C., Agosto, P., Miller, J., Waqar, L., Gerdes, M., Bernbaum, J., Rosenthal, H., Rintoul, N., Herkert, L., Peranteau, W., Flake, A., Adzick, N., & Hedrick, H. (2018). Rate and Risk Factors Associated with Autism Spectrum Disorder in Congenital Diaphragmatic Hernia.. Journal of autism and developmental disorders, 48 (6), 2112-2121. https://doi.org/10.1007/s10803-018-3472-6
